3way: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_3way|  PDB=3way  |  SCENE=  }}
+===Crystal Structure of Autotaxin in Complex with 4BoA===
+{{ABSTRACT_PUBMED_23688339}}
-The entry 3way is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE]] Note=May contribute to obesity.
-Authors: Nishimasu, H., Ishitani, R., Nureki, O.
+==Function==
+[[http://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE]] Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.<ref>PMID:15700135</ref> <ref>PMID:17208043</ref> <ref>PMID:21240269</ref>
-Description: Crystal Structure of Autotaxin in Complex with 4BoA
+==About this Structure==
+[[3way]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WAY OCA].
+==Reference==
+<ref group="xtra">PMID:023688339</ref><references group="xtra"/><references/>
+[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
+[[Category: Mus musculus]]
+[[Category: Ishitani, R.]]
+[[Category: Nishimasu, H.]]
+[[Category: Nureki, O.]]
+[[Category: Hydrolase]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]