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{{STRUCTURE_4lb0|  PDB=4lb0  |  SCENE=  }}
===Crystal structure of a hydroxyproline epimerase from agrobacterium vitis, target efi-506420, with bound trans-4-oh-l-proline===


==About this Structure==
==Crystal structure of a hydroxyproline epimerase from agrobacterium vitis, target efi-506420, with bound trans-4-oh-l-proline==
[[4lb0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_vitis_s4 Agrobacterium vitis s4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LB0 OCA].  
<StructureSection load='4lb0' size='340' side='right' caption='[[4lb0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
[[Category: Agrobacterium vitis s4]]
== Structural highlights ==
[[Category: Almo, S C.]]
<table><tr><td colspan='2'>[[4lb0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrvs Agrvs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LB0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LB0 FirstGlance]. <br>
[[Category: Bhosle, R.]]
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
[[Category: Chowdhury, S.]]
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Avi_0518 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=311402 AGRVS])</td></tr>
[[Category: EFI, Enzyme Function Initiative.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lb0 OCA], [http://pdbe.org/4lb0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lb0 RCSB], [http://www.ebi.ac.uk/pdbsum/4lb0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lb0 ProSAT]</span></td></tr>
[[Category: Evans, B.]]
</table>
[[Category: Gerlt, J A.]]
== Function ==
[[Category: Glenn, A S.]]
[[http://www.uniprot.org/uniprot/4HYPE_AGRVS 4HYPE_AGRVS]] Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). May be involved in a degradation pathway of t4LHyp. Can also catalyze the epimerization of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp) in vitro. Displays no proline racemase activity.<ref>PMID:24980702</ref> 
[[Category: Hammonds, J.]]
== References ==
[[Category: Hillerich, B.]]
<references/>
[[Category: Imker, H J.]]
__TOC__
[[Category: Love, J.]]
</StructureSection>
[[Category: Morisco, L L.]]
[[Category: Agrvs]]
[[Category: Obaidi, N F.Al.]]
[[Category: Almo, S C]]
[[Category: Seidel, R D.]]
[[Category: Bhosle, R]]
[[Category: Sojitra, S.]]
[[Category: Chowdhury, S]]
[[Category: Stead, M.]]
[[Category: EFI, Enzyme Function Initiative]]
[[Category: Toro, R.]]
[[Category: Evans, B]]
[[Category: Vetting, M W.]]
[[Category: Gerlt, J A]]
[[Category: Washington, E.]]
[[Category: Glenn, A S]]
[[Category: Wasserman, S R.]]
[[Category: Hammonds, J]]
[[Category: Hillerich, B]]
[[Category: Imker, H J]]
[[Category: Love, J]]
[[Category: Morisco, L L]]
[[Category: Obaidi, N F.Al]]
[[Category: Seidel, R D]]
[[Category: Sojitra, S]]
[[Category: Stead, M]]
[[Category: Toro, R]]
[[Category: Vetting, M W]]
[[Category: Washington, E]]
[[Category: Wasserman, S R]]
[[Category: Efi]]
[[Category: Efi]]
[[Category: Enzyme function initiative]]
[[Category: Enzyme function initiative]]

Revision as of 13:35, 4 August 2016

Crystal structure of a hydroxyproline epimerase from agrobacterium vitis, target efi-506420, with bound trans-4-oh-l-prolineCrystal structure of a hydroxyproline epimerase from agrobacterium vitis, target efi-506420, with bound trans-4-oh-l-proline

Structural highlights

4lb0 is a 2 chain structure with sequence from Agrvs. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:Avi_0518 (AGRVS)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[4HYPE_AGRVS] Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). May be involved in a degradation pathway of t4LHyp. Can also catalyze the epimerization of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp) in vitro. Displays no proline racemase activity.[1]

References

  1. ↑ Zhao S, Sakai A, Zhang X, Vetting MW, Kumar R, Hillerich B, San Francisco B, Solbiati J, Steves A, Brown S, Akiva E, Barber A, Seidel RD, Babbitt PC, Almo SC, Gerlt JA, Jacobson MP. Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks. Elife. 2014 Jun 30;3. doi: 10.7554/eLife.03275. PMID:24980702 doi:http://dx.doi.org/10.7554/eLife.03275

4lb0, resolution 1.70Å

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