4krl: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4krl|  PDB=4krl  |  SCENE=  }}
+===Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 6.0===
+{{ABSTRACT_PUBMED_23791944}}
-The entry 4krl is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/EGFR_HUMAN EGFR_HUMAN]] Defects in EGFR are associated with lung cancer (LNCR) [MIM:[http://omim.org/entry/211980 211980]]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
-Authors: Ferguson, K.M., Schmitz, R.K.
+==Function==
+[[http://www.uniprot.org/uniprot/EGFR_HUMAN EGFR_HUMAN]] Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.<ref>PMID:7657591</ref> <ref>PMID:11602604</ref> <ref>PMID:12873986</ref> <ref>PMID:10805725</ref> <ref>PMID:11116146</ref> <ref>PMID:11483589</ref> <ref>PMID:17115032</ref> <ref>PMID:21258366</ref> <ref>PMID:12297050</ref> <ref>PMID:12620237</ref> <ref>PMID:15374980</ref> <ref>PMID:19560417</ref> <ref>PMID:20837704</ref>   Isoform 2 may act as an antagonist of EGF action.<ref>PMID:7657591</ref> <ref>PMID:11602604</ref> <ref>PMID:12873986</ref> <ref>PMID:10805725</ref> <ref>PMID:11116146</ref> <ref>PMID:11483589</ref> <ref>PMID:17115032</ref> <ref>PMID:21258366</ref> <ref>PMID:12297050</ref> <ref>PMID:12620237</ref> <ref>PMID:15374980</ref> <ref>PMID:19560417</ref> <ref>PMID:20837704</ref>
-Description: Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 6.0
+==About this Structure==
+[[4krl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRL OCA].
+==Reference==
+<ref group="xtra">PMID:023791944</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Lama glama]]
+[[Category: Receptor protein-tyrosine kinase]]
+[[Category: Ferguson, K M.]]
+[[Category: Schmitz, K R.]]
+[[Category: Antibody]]
+[[Category: Antibody complex]]
+[[Category: Antigen]]
+[[Category: Camelid vh domain]]
+[[Category: Cell surface receptor]]
+[[Category: Glycoprotein]]
+[[Category: Nanobody]]
+[[Category: Transferase-immune system complex]]
+[[Category: Vhh domain]]