4j51: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4j51|  PDB=4j51  |  SCENE=  }}
+===Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04===
+{{ABSTRACT_PUBMED_23713581}}
-The entry 4j51 is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN]] Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:[http://omim.org/entry/152700 152700]]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:15273934</ref>
-Authors: Liu, D., He, Y., Zhang, Z.-Y.
+==Function==
+[[http://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN]] Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.<ref>PMID:16461343</ref> <ref>PMID:18056643</ref> <ref>PMID:19167335</ref> <ref>PMID:21719704</ref>
-Description: Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04
+==About this Structure==
+[[4j51]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J51 OCA].
+==Reference==
+<ref group="xtra">PMID:023713581</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Protein-tyrosine-phosphatase]]
+[[Category: He, Y.]]
+[[Category: Liu, D.]]
+[[Category: Zhang, Z Y.]]
+[[Category: Hydrolase]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Inhibitor design]]
+[[Category: Tyrosine phosphatase]]