4f4b: Difference between revisions

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{{STRUCTURE_4f4b| PDB=4f4b | SCENE= }}
==Structure of OSH4 with a cholesterol analog==
===Structure of OSH4 with a cholesterol analog===
<StructureSection load='4f4b' size='340' side='right' caption='[[4f4b]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
{{ABSTRACT_PUBMED_23756172}}
== Structural highlights ==
<table><tr><td colspan='2'>[[4f4b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F4B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L39:(3BETA,9BETA,25R)-3-HYDROXY-26-IODOCHOLEST-5-ENE-16,22-DIONE'>L39</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zhy|1zhy]], [[1zhx|1zhx]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KES1, OSH4, YPL145C, LPI3C, P2614 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f4b RCSB], [http://www.ebi.ac.uk/pdbsum/4f4b PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We have synthesized 16,22-diketocholesterol, a novel ligand for oxysterol-binding protein Osh4, and determined X-ray structure of the diketocholesterol in complex with Osh4. The X-ray structure shows that alpha7 helix of Osh4 assumes open conformation while the rest of Osh4, closed conformation, implying this diketocholesterol-bound Osh4 structure may represent a structural intermediate between the two conformations.


==About this Structure==
Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.,Koag MC, Cheun Y, Kou Y, Ouzon-Shubeita H, Min K, Monzingo AF, Lee S Steroids. 2013 Jun 10;78(9):938-944. doi: 10.1016/j.steroids.2013.05.016. PMID:23756172<ref>PMID:23756172</ref>
[[4f4b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4B OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<ref group="xtra">PMID:023756172</ref><references group="xtra"/><references/>
</div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Cheun, Y.]]
[[Category: Cheun, Y]]
[[Category: Koag, M C.]]
[[Category: Koag, M C]]
[[Category: Lee, S.]]
[[Category: Lee, S]]
[[Category: Monzingo, A F.]]
[[Category: Monzingo, A F]]
[[Category: Lipid binding protein]]
[[Category: Lipid binding protein]]
[[Category: Oxysterol]]
[[Category: Oxysterol]]
[[Category: Sterol binding protein]]
[[Category: Sterol binding protein]]

Revision as of 17:19, 4 January 2015

Structure of OSH4 with a cholesterol analogStructure of OSH4 with a cholesterol analog

Structural highlights

4f4b is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:KES1, OSH4, YPL145C, LPI3C, P2614 (Saccharomyces cerevisiae S288c)
Resources:FirstGlance, OCA, RCSB, PDBsum

Publication Abstract from PubMed

We have synthesized 16,22-diketocholesterol, a novel ligand for oxysterol-binding protein Osh4, and determined X-ray structure of the diketocholesterol in complex with Osh4. The X-ray structure shows that alpha7 helix of Osh4 assumes open conformation while the rest of Osh4, closed conformation, implying this diketocholesterol-bound Osh4 structure may represent a structural intermediate between the two conformations.

Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.,Koag MC, Cheun Y, Kou Y, Ouzon-Shubeita H, Min K, Monzingo AF, Lee S Steroids. 2013 Jun 10;78(9):938-944. doi: 10.1016/j.steroids.2013.05.016. PMID:23756172[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Koag MC, Cheun Y, Kou Y, Ouzon-Shubeita H, Min K, Monzingo AF, Lee S. Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4. Steroids. 2013 Jun 10;78(9):938-944. doi: 10.1016/j.steroids.2013.05.016. PMID:23756172 doi:10.1016/j.steroids.2013.05.016

4f4b, resolution 1.87Å

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