NF-kB: Difference between revisions

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Michal Harel, Alexander Berchansky

Revision as of 11:38, 17 July 2013 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Revision as of 11:38, 17 July 2013 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary Newer edit →
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	<StructureSection load='1nfk' size='350' side='right' caption='Structure of ~~human~~ NF-kB1 p50 complex with DNA (PDB entry [[1nfk]])' scene=''>		<StructureSection load='1nfk' size='350' side='right' caption='Structure of mouse NF-kB1 p50 complex with DNA (PDB entry [[1nfk]])' scene=''>

	'''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA. There are 5 proteins in the NF-kB family: '''NF-kB1''' (synthesized as '''p105''' and processed to '''p50'''), '''NF-kB2''' (synthesized as '''p100''' and processed to '''p52'''), '''RelA''' (or '''p65'''), '''RelB''' and '''cRel'''. I-κ-B-α is an inhibitor of NF-kB.		'''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA. There are 5 proteins in the NF-kB family: '''NF-kB1''' (synthesized as '''p105''' and processed to '''p50'''), '''NF-kB2''' (synthesized as '''p100''' and processed to '''p52'''), '''RelA''' (or '''p65'''), '''RelB''' and '''cRel'''. I-κ-B-α is an inhibitor of NF-kB.