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==Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid== | |||
<StructureSection load='4jql' size='340' side='right' caption='[[4jql]], [[Resolution|resolution]] 1.72Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4jql]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JQL FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VJ6:VALERJESOMYCIN'>VJ6</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jql OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jql RCSB], [http://www.ebi.ac.uk/pdbsum/4jql PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
One is not like the other: The title approach proceeds by stepwise coupling of three relatively simple substrates. Three natural product-inspired agents are described, one of which has natural product-like toxicity for HeLa and MCF7 cells. It is isoform-selective, thus targeting Hsp90alpha/beta over Grp94, and adopts a conformation similar to that of geldanamycin when complexed with Hsp90. | |||
Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic Acid.,Jeso V, Iqbal S, Hernandez P, Cameron MD, Park H, Lograsso PV, Micalizio GC Angew Chem Int Ed Engl. 2013 Apr 26;52(18):4800-4. doi: 10.1002/anie.201301323., Epub 2013 Apr 2. PMID:23554224<ref>PMID:23554224</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== | ==See Also== | ||
*[[Heat Shock Proteins|Heat Shock Proteins]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Cameron, M D | [[Category: Cameron, M D]] | ||
[[Category: Hernandez, P | [[Category: Hernandez, P]] | ||
[[Category: Iqbal, S | [[Category: Iqbal, S]] | ||
[[Category: Jeso, V | [[Category: Jeso, V]] | ||
[[Category: Lograsso, P V | [[Category: Lograsso, P V]] | ||
[[Category: Micalizio, G C | [[Category: Micalizio, G C]] | ||
[[Category: Park, H | [[Category: Park, H]] | ||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Chaperone-inhibitor complex]] | [[Category: Chaperone-inhibitor complex]] | ||