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{{STRUCTURE_2lsi|  PDB=2lsi  |  SCENE=  }}
==Solution structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase kappa==
===Solution structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase kappa===
<StructureSection load='2lsi' size='340' side='right' caption='[[2lsi]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[2lsi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LSI FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN]] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref> [[http://www.uniprot.org/uniprot/POLK_HUMAN POLK_HUMAN]] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.<ref>PMID:10620008</ref> <ref>PMID:11024016</ref> <ref>PMID:12145297</ref> <ref>PMID:12444249</ref> <ref>PMID:12952891</ref> <ref>PMID:14630940</ref> <ref>PMID:15533436</ref>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">REV1, REV1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
 
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lsi RCSB], [http://www.ebi.ac.uk/pdbsum/2lsi PDBsum]</span></td></tr>
[[2lsi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSI OCA].  
</table>
 
__TOC__
==Reference==
</StructureSection>
<references group="xtra"/><references/>
[[Category: DNA-directed DNA polymerase]]
[[Category: DNA-directed DNA polymerase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Choi, B.]]
[[Category: Choi, B]]
[[Category: Ko, J.]]
[[Category: Ko, J]]
[[Category: Liu, D.]]
[[Category: Liu, D]]
[[Category: Ryu, K.]]
[[Category: Ryu, K]]
[[Category: Polymerase kappa]]
[[Category: Polymerase kappa]]
[[Category: Polymerase-interacting domain]]
[[Category: Polymerase-interacting domain]]

Revision as of 14:19, 18 December 2014

Solution structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase kappaSolution structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase kappa

Structural highlights

2lsi is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:REV1, REV1L (Homo sapiens)
Activity:DNA-directed DNA polymerase, with EC number 2.7.7.7
Resources:FirstGlance, OCA, RCSB, PDBsum
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