2hey: Difference between revisions

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Revision as of 18:16, 20 March 2008

File:2hey.gif

, resolution 2.00Å

Ligands:

Gene:

Tnfsf4, Ox40l, Txgp1l (Mus musculus), TNFRSF4, TXGP1L (Homo sapiens)

Coordinates:

save as pdb, mmCIF, xml

Crystal structure of murine OX40L bound to human OX40

OverviewOverview

OX40 is a T cell costimulator activated by OX40L. Blockade of the OX40L-OX40 interaction has ameliorative effects in animal models of T cell pathologies. In order to better understand the interaction between OX40 and OX40L, we have determined the crystal structure of murine OX40L and of the human OX40-OX40L complex at 1.45 and 2.4 A, respectively. These structures show that OX40L is an unusually small member of the tumor necrosis factor superfamily (TNFSF). The arrangement of the OX40L protomers forming the functional trimer is atypical and differs from that of other members by a 15 degrees rotation of each protomer with respect to the trimer axis, resulting in an open assembly. Site-directed changes of the interfacial residues of OX40L suggest this interface lacks a single "hot spot" and that instead, binding energy is dispersed over at least two distinct areas. These structures demonstrate the structural plasticity of TNFSF members and their interactions with receptors.

About this StructureAbout this Structure

2HEY is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of the costimulatory OX40-OX40L complex., Compaan DM, Hymowitz SG, Structure. 2006 Aug;14(8):1321-30. PMID:16905106

Page seeded by OCA on Thu Mar 20 17:16:16 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2hey.gif|left|200px]]<br /><applet load="2hey" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2hey.gif|left|200px]]
-caption="2hey, resolution 2.00&Aring;" />
-'''Crystal structure of murine OX40L bound to human OX40'''<br />
+ {{Structure
+|PDB= 2hey |SIZE=350|CAPTION= <scene name='initialview01'>2hey</scene>, resolution 2.00&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
+|ACTIVITY=
+|GENE= Tnfsf4, Ox40l, Txgp1l ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), TNFRSF4, TXGP1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''Crystal structure of murine OX40L bound to human OX40'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-HEY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA].
+HEY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA].
 ==Reference==
-The crystal structure of the costimulatory OX40-OX40L complex., Compaan DM, Hymowitz SG, Structure. 2006 Aug;14(8):1321-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16905106 16905106]
+The crystal structure of the costimulatory OX40-OX40L complex., Compaan DM, Hymowitz SG, Structure. 2006 Aug;14(8):1321-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16905106 16905106]
 [[Category: Homo sapiens]]
 [[Category: Mus musculus]]
@@ Line 21: / Line 30: @@
 [[Category: tnfsf]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:41:16 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:16:16 2008''