2hdc: Difference between revisions
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[[Image:2hdc.gif|left|200px]] | [[Image:2hdc.gif|left|200px]] | ||
'''STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX''' | {{Structure | ||
|PDB= 2hdc |SIZE=350|CAPTION= <scene name='initialview01'>2hdc</scene> | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= GENESIS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | |||
}} | |||
'''STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2HDC is a [ | 2HDC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDC OCA]. | ||
==Reference== | ==Reference== | ||
Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex., Jin C, Marsden I, Chen X, Liao X, J Mol Biol. 1999 Jun 18;289(4):683-90. PMID:[http:// | Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex., Jin C, Marsden I, Chen X, Liao X, J Mol Biol. 1999 Jun 18;289(4):683-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10369754 10369754] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Liao, X.]] | [[Category: Liao, X.]] | ||
[[Category: Marsden, I.]] | [[Category: Marsden, I.]] | ||
[[Category: | [[Category: dyanamic]] | ||
[[Category: genesis]] | [[Category: genesis]] | ||
[[Category: nmr]] | [[Category: nmr]] | ||
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[[Category: winged helix protein]] | [[Category: winged helix protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:15:41 2008'' | ||
Revision as of 18:15, 20 March 2008
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| Gene: | GENESIS (Rattus norvegicus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX
OverviewOverview
Genesis is an HNF-3/fkh homologous protein. By using multi-dimensional NMR techniques, we have obtained the solution structure and backbone dynamics of Genesis complexed with a 17 base-pair DNA. Our results indicate that both the local folding and dynamic properties of Genesis are perturbed when it binds to the DNA site. Our data show that a conserved flexible amino acid sequence (wing 1) makes dynamic contacts to DNA in the complex and a short helix is induced by Genesis-DNA interactions. Our data indicate that, unlike the HNF-3gamma/DNA complex, a magnesium ion is not required in forming the stable Genesis-DNA complex.
About this StructureAbout this Structure
2HDC is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
ReferenceReference
Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex., Jin C, Marsden I, Chen X, Liao X, J Mol Biol. 1999 Jun 18;289(4):683-90. PMID:10369754
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