4kp5: Difference between revisions
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{{STRUCTURE_4kp5| PDB=4kp5 | SCENE= }} | |||
===Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide=== | |||
{{ABSTRACT_PUBMED_24103428}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN]] Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:[http://omim.org/entry/143860 143860]]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.<ref>PMID:21035102</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN]] Reversible hydration of carbon dioxide. | |||
==About this Structure== | |||
[[4kp5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP5 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024103428</ref><references group="xtra"/><references/> | |||
[[Category: Carbonate dehydratase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Grazulis, S.]] | |||
[[Category: Manakova, E.]] | |||
[[Category: Smirnov, A.]] | |||
[[Category: Benzenesulfonamide]] | |||
[[Category: Carbonic anhydrase]] | |||
[[Category: Drug design]] | |||
[[Category: Lyase-lyase inhibitor complex]] | |||
[[Category: Metal-binding]] | |||