4bqs: Difference between revisions
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{{STRUCTURE_4bqs| PDB=4bqs | SCENE= }} | |||
===Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with ADP and a shikimic acid derivative.=== | |||
{{ABSTRACT_PUBMED_23889343}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref> | |||
==About this Structure== | |||
[[4bqs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQS OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023889343</ref><references group="xtra"/><references/> | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Shikimate kinase]] | |||
[[Category: Blanco, B.]] | |||
[[Category: Garcia-Doval, C.]] | |||
[[Category: Gonzalez-Bello, C.]] | |||
[[Category: Hawkins, A R.]] | |||
[[Category: Lamb, H.]] | |||
[[Category: Lence, E.]] | |||
[[Category: Llamas-Saiz, A L.]] | |||
[[Category: Otero, J M.]] | |||
[[Category: Prado, V.]] | |||
[[Category: VanRaaij, M J.]] | |||
[[Category: Inhibitor]] | |||
[[Category: Shikimic acid pathway]] | |||
[[Category: Transferase]] | |||
Revision as of 23:52, 7 August 2013
Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with ADP and a shikimic acid derivative.Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with ADP and a shikimic acid derivative.
Template:ABSTRACT PUBMED 23889343
FunctionFunction
[AROK_MYCTU] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.[1] [2]
About this StructureAbout this Structure
4bqs is a 3 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Blanco B, Prado V, Lence E, Otero JM, Garcia-Doval C, van Raaij MJ, Llamas-Saiz AL, Lamb H, Hawkins AR, Gonzalez-Bello C. Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover J Am Chem Soc. 2013 Jul 26. PMID:23889343 doi:10.1021/ja405853p
- ↑ Oliveira JS, Pinto CA, Basso LA, Santos DS. Cloning and overexpression in soluble form of functional shikimate kinase and 5-enolpyruvylshikimate 3-phosphate synthase enzymes from Mycobacterium tuberculosis. Protein Expr Purif. 2001 Aug;22(3):430-5. PMID:11483005 doi:10.1006/prep.2001.1457
- ↑ Hartmann MD, Bourenkov GP, Oberschall A, Strizhov N, Bartunik HD. Mechanism of phosphoryl transfer catalyzed by shikimate kinase from Mycobacterium tuberculosis. J Mol Biol. 2006 Dec 1;364(3):411-23. Epub 2006 Sep 5. PMID:17020768 doi:10.1016/j.jmb.2006.09.001