3wc8: Difference between revisions
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{{STRUCTURE_3wc8| PDB=3wc8 | SCENE= }} | |||
===Dimeric horse cytochrome c obtained by refolding with desalting method=== | |||
{{ABSTRACT_PUBMED_24206001}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/CYC_HORSE CYC_HORSE]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity). | |||
==About this Structure== | |||
[[3wc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WC8 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024206001</ref><references group="xtra"/><references/> | |||
[[Category: Equus caballus]] | |||
[[Category: Deshpande, M S.]] | |||
[[Category: Higuchi, Y.]] | |||
[[Category: Hirota, S.]] | |||
[[Category: Kamikubo, H.]] | |||
[[Category: Kataoka, M.]] | |||
[[Category: Komori, H.]] | |||
[[Category: Nagao, S.]] | |||
[[Category: Parui, P P.]] | |||
[[Category: Electron transport]] | |||
Revision as of 16:33, 11 December 2013
Dimeric horse cytochrome c obtained by refolding with desalting methodDimeric horse cytochrome c obtained by refolding with desalting method
Template:ABSTRACT PUBMED 24206001
FunctionFunction
[CYC_HORSE] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
About this StructureAbout this Structure
3wc8 is a 1 chain structure with sequence from Equus caballus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Parui PP, Deshpande MS, Nagao S, Kamikubo H, Komori H, Higuchi Y, Kataoka M, Hirota S. Formation of Oligomeric Cytochrome c during Folding by Intermolecular Hydrophobic Interaction between N- and C-Terminal alpha-Helices. Biochemistry. 2013 Dec 3;52(48):8732-44. doi: 10.1021/bi400986g. Epub 2013 Nov, 20. PMID:24206001 doi:http://dx.doi.org/10.1021/bi400986g