4km5: Difference between revisions
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{{STRUCTURE_4km5| PDB=4km5 | SCENE= }} | |||
===X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS)=== | |||
{{ABSTRACT_PUBMED_23707061}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | |||
==About this Structure== | |||
[[4km5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM5 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023707061</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Berger, J M.]] | |||
[[Category: Doudna, J A.]] | |||
[[Category: Kranzusch, P J.]] | |||
[[Category: Lee, A S.Y.]] | |||
[[Category: Cytoplasmic]] | |||
[[Category: Dna]] | |||
[[Category: Dna sensor]] | |||
[[Category: Innate immunity]] | |||
[[Category: Nucleotidyl transferase]] | |||
[[Category: Transferase]] | |||
[[Category: Zinc finger]] | |||
Revision as of 16:48, 19 June 2013
X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS)X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS)
Template:ABSTRACT PUBMED 23707061
FunctionFunction
[CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.[1] [2]
About this StructureAbout this Structure
4km5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Kranzusch PJ, Lee AS, Berger JM, Doudna JA. Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity. Cell Rep. 2013 May 30;3(5):1362-8. doi: 10.1016/j.celrep.2013.05.008. Epub 2013, May 23. PMID:23707061 doi:10.1016/j.celrep.2013.05.008
- ↑ Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature. 2011 Apr 28;472(7344):481-5. doi: 10.1038/nature09907. Epub 2011 Apr 10. PMID:21478870 doi:10.1038/nature09907
- ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458