Fibroblast growth factor receptor: Difference between revisions
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{{STRUCTURE_1evt| PDB=1evt | SIZE=400| SCENE= |right|CAPTION= Human fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 (pink and yellow) complex with fibroblast growth factor 1 (grey and green), [[1evt]] }} | {{STRUCTURE_1evt| PDB=1evt | SIZE=400| SCENE= |right|CAPTION= Human fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 (pink and yellow) complex with fibroblast growth factor 1 (grey and green) and sulfate, [[1evt]] }} | ||
'''Fibroblast growth factor receptors''' (FGFR) are receptors which bind fibroblast growth factors (FGF). FGFR consist of an extracellular ligand-binding domain (LBD), transmembrane helix domain and cytoplasmic tyrosine kinase activity domain (TKD) with phosphorylated tyrosine designated PTR. FGFR LBD contains 3 immunoglobulin-like domains D1, D2 and D3. Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation. | '''Fibroblast growth factor receptors''' (FGFR) are receptors which bind fibroblast growth factors (FGF). FGFR consist of an extracellular ligand-binding domain (LBD), transmembrane helix domain and cytoplasmic tyrosine kinase activity domain (TKD) with phosphorylated tyrosine designated PTR. FGFR LBD contains 3 immunoglobulin-like domains D1, D2 and D3. Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation. | ||
Revision as of 14:20, 11 December 2013
Fibroblast growth factor receptors (FGFR) are receptors which bind fibroblast growth factors (FGF). FGFR consist of an extracellular ligand-binding domain (LBD), transmembrane helix domain and cytoplasmic tyrosine kinase activity domain (TKD) with phosphorylated tyrosine designated PTR. FGFR LBD contains 3 immunoglobulin-like domains D1, D2 and D3. Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation.
3D structures of fibroblast growth factor receptor3D structures of fibroblast growth factor receptor
Updated on 11-December-2013
FGFR1FGFR1
FGFR1 tyrosine kinase domain
1fgk, 3kxx, 3ky2 – hFGFR1 TKD (mutant) - human
1agw, 1fgi, 2fgi, 3c4f, 3js2, 3rhx, 4f63, 4f64, 4f65, 3tt0 – hFGFR1 TKD (mutant) + inhibitor
3krj – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor
1xr0 – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR
3gqi – hFGFR1 TKD (mutant) with PTR + ACP
3gql – hFGFR1 TKD (mutant) + substrate
FGFR1 ligand-binding domain
2cr3 – hFGFR1 LBD D1 - NMR
2ckn – FGFR1 LBD D1 – mouse - NMR
FGFR1 complex with FGF
3ojv – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human
1cvs – hFGFR1 LBD D2,D3 (mutant) + hFGF2 (mutant)
1evt – hFGFR1 LBD D2,D3 + hFGF1
1fq9 – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS
FGFR2FGFR2
FGFR2 tyrosine kinase domain
1gjo, 1oec, 2psq – hFGFR2 TKD
2pvy, 2pwl, 2py3, 2pz5, 2pzp, 2pzr, 2q0b – hFGFR2 TKD (mutant) + ACP
3b2t – hFGFR2 TKD (mutant) + adenosine derivative
2pvf – hFGFR2 TKD with PTR + ACP + substrate peptide
3cly – hFGFR2 TKD (mutant) with PTR + ACP
3ri1 – hFGFR2 TKD + inhibitor
FGFR2 ligand-binding domain
3dar, 3caf, 3euu – hFGFR2 LBD D2
4hwu – hFGFR2 LBD D1
FGFR2 complex with FGF
1e0o – hFGFR2 (mutant) LBD D2,D3 + hFGF1 (mutant) + HS
3oj2, 3ojm – hFGFR2 (mutant) LBD D2,D3 + hFGF1
1djs – hFGFR2 LBD D2,D3 (mutant) + hFGF1
1ev2, 1ii4, 1iil – hFGFR2 LBD D2,D3 + hFGF2 (mutant)
3cu1 – hFGFR2 LBD D2 + hFGF1
2fdb – hFGFR2 LBD D2,D3 + hFGF8b
1nun – hFGFR2 LBD D2,D3 + hFGF10
FGFR3FGFR3
3grw – hFGFR3 LBD D2,D3 + antibody
FGFR3 complex with FGF
1ry7 – hFGFR3 LBD + hFGF1