2fug: Difference between revisions
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[[Image:2fug.gif|left|200px]] | [[Image:2fug.gif|left|200px]] | ||
'''Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus''' | {{Structure | ||
|PDB= 2fug |SIZE=350|CAPTION= <scene name='initialview01'>2fug</scene>, resolution 3.300Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene> and <scene name='pdbligand=FMN:FLAVIN MONONUCLEOTIDE'>FMN</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/NADH_dehydrogenase_(quinone) NADH dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.99.5 1.6.99.5] | |||
|GENE= | |||
}} | |||
'''Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2FUG is a [ | 2FUG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FUG OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus., Sazanov LA, Hinchliffe P, Science. 2006 Mar 10;311(5766):1430-6. Epub 2006 Feb 9. PMID:[http:// | Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus., Sazanov LA, Hinchliffe P, Science. 2006 Mar 10;311(5766):1430-6. Epub 2006 Feb 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16469879 16469879] | ||
[[Category: NADH dehydrogenase (quinone)]] | [[Category: NADH dehydrogenase (quinone)]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: respiratory chain]] | [[Category: respiratory chain]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:56:52 2008'' | ||
Revision as of 17:56, 20 March 2008
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| , resolution 3.300Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Activity: | NADH dehydrogenase (quinone), with EC number 1.6.99.5 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus
OverviewOverview
Respiratory complex I plays a central role in cellular energy production in bacteria and mitochondria. Its dysfunction is implicated in many human neurodegenerative diseases, as well as in aging. The crystal structure of the hydrophilic domain (peripheral arm) of complex I from Thermus thermophilus has been solved at 3.3 angstrom resolution. This subcomplex consists of eight subunits and contains all the redox centers of the enzyme, including nine iron-sulfur clusters. The primary electron acceptor, flavin-mononucleotide, is within electron transfer distance of cluster N3, leading to the main redox pathway, and of the distal cluster N1a, a possible antioxidant. The structure reveals new aspects of the mechanism and evolution of the enzyme. The terminal cluster N2 is coordinated, uniquely, by two consecutive cysteines. The novel subunit Nqo15 has a similar fold to the mitochondrial iron chaperone frataxin, and it may be involved in iron-sulfur cluster regeneration in the complex.
About this StructureAbout this Structure
2FUG is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus., Sazanov LA, Hinchliffe P, Science. 2006 Mar 10;311(5766):1430-6. Epub 2006 Feb 9. PMID:16469879
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