G1SecL05: Difference between revisions
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===Structure of LA-2 ospA complex === | ===Structure of LA-2 ospA complex === | ||
LA-2 fab recognizes the three surface-exposed loops; loop1, loop 2 and loop 3 of the C-terminal domain of OspA that are on the tip of the elongated molecule most distant from the lipid-modified N terminus. Residues 203 to 220 in “loop 1“ , residues 224 to 233 in “loop 2“ and residues 246 to 257 in “loop 3“are mostly effected by la-2 binding. In loop 1 residues 206 and 216 are not affected. The interactions between OspA and LA-2 include eight direct hydrogen bonds, four solvent-bridged hydrogen bonds, three ion pairs, and numerous van der Waals interactions.<ref> | LA-2 fab recognizes the three surface-exposed loops; loop1, loop 2 and loop 3 of the C-terminal domain of OspA that are on the tip of the elongated molecule most distant from the lipid-modified N terminus. Residues 203 to 220 in “loop 1“ , residues 224 to 233 in “loop 2“ and residues 246 to 257 in “loop 3“are mostly effected by la-2 binding. In loop 1 residues 206 and 216 are not affected. The interactions between OspA and LA-2 include eight direct hydrogen bonds, four solvent-bridged hydrogen bonds, three ion pairs, and numerous van der Waals interactions.<ref>7</ref> | ||
<Structure load='1fj1' size='500' frame='true' align='right' caption='3D Jmol model' | <Structure load='1fj1' size='500' frame='true' align='right' caption='3D Jmol model' | ||
scene='Insert optional scene name here' /> | scene='Insert optional scene name here' /> | ||