G1SecL05: Difference between revisions
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Although the LA-2- ospA complex induces a high reactivity of protective immune response for ''B. burgdorferi'', it lacks the broad specificity to encompass other genospecies of ''Borrelia''. In North America, Lyme borreliosis is caused by a single strain ''B.burgdorferi'', whereas in parts of Europe and Asia, a minimum of three strains, ''B. afzelli'', ''B. burgdorferi'', and ''B. garinii'' are involved in infecting humans<ref>PMID: 21217174</ref>. The lack of broad specificity in the LA-2- OspA complex is due to the presence of highly variable regions in ospA. | Although the LA-2- ospA complex induces a high reactivity of protective immune response for ''B. burgdorferi'', it lacks the broad specificity to encompass other genospecies of ''Borrelia''. In North America, Lyme borreliosis is caused by a single strain ''B.burgdorferi'', whereas in parts of Europe and Asia, a minimum of three strains, ''B. afzelli'', ''B. burgdorferi'', and ''B. garinii'' are involved in infecting humans<ref>PMID: 21217174</ref>. The lack of broad specificity in the LA-2- OspA complex is due to the presence of highly variable regions in ospA. | ||
===Trp -216=== | |||
<scene name='G1SecL05/1fj1-condensed/1'>Composite Three variable regions highlights, Tryptophan 216 - Blue, Alanine 208 - Purple, Highly Variable LA-2 Fab + OspA conjunction - Red</scene> | |||
===Ala-208=== | |||
===Residues 217-237=== | |||
<Structure load='1fj1' size='500' frame='true' align='right' caption='3D Jmol model' scene='Insert optional scene name here' /> | <Structure load='1fj1' size='500' frame='true' align='right' caption='3D Jmol model' scene='Insert optional scene name here' /> | ||
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<scene name='G1SecL05/1fj1_chains_labeled/1'>Chains A-E labeled</scene> | <scene name='G1SecL05/1fj1_chains_labeled/1'>Chains A-E labeled</scene> | ||
==References== | ==References== | ||
<references /> | <references /> | ||