G1SecL05: Difference between revisions
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==Inefficiency and concerns== | ==Inefficiency and concerns== | ||
Although the LA-2- ospA complex induces a high reactivity of protective immune response for B. burgdorferi, it lacks the broad specificity to encompass other genospecies of Borrelia. In North America, Lyme borreliosis is caused by a single strain B.burgdorferi, whereas in parts of Europe and Asia, a minimum of three strains, B. afzelli, B. burgdorferi, and B. garinii are involved in infecting humans | Although the LA-2- ospA complex induces a high reactivity of protective immune response for ''B. burgdorferi'', it lacks the broad specificity to encompass other genospecies of ''Borrelia''. In North America, Lyme borreliosis is caused by a single strain ''B.burgdorferi'', whereas in parts of Europe and Asia, a minimum of three strains, ''B. afzelli'', ''B. burgdorferi'', and ''B. garinii'' are involved in infecting humans<ref>PMID: 21217174</ref>. The lack of broad specificity in the LA-2- OspA complex is due to the presence of highly variable regions in ospA. | ||