2fom: Difference between revisions

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Revision as of 17:54, 20 March 2008

File:2fom.gif

, resolution 1.50Å

Ligands:

and

Activity:

Flavivirin, with EC number 3.4.21.91

Coordinates:

save as pdb, mmCIF, xml

Dengue Virus NS2B/NS3 Protease

OverviewOverview

The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.

About this StructureAbout this Structure

2FOM is a Protein complex structure of sequences from Dengue virus type 3. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:16532006

Page seeded by OCA on Thu Mar 20 16:54:57 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2fom.gif|left|200px]]<br /><applet load="2fom" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2fom.gif|left|200px]]
-caption="2fom, resolution 1.50&Aring;" />
-'''Dengue Virus NS2B/NS3 Protease'''<br />
+ {{Structure
+|PDB= 2fom |SIZE=350|CAPTION= <scene name='initialview01'>2fom</scene>, resolution 1.50&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91]
+|GENE=
+}}
+'''Dengue Virus NS2B/NS3 Protease'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-FOM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Dengue_virus_type_3 Dengue virus type 3] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FOM OCA].
+FOM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Dengue_virus_type_3 Dengue virus type 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FOM OCA].
 ==Reference==
-Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16532006 16532006]
+Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16532006 16532006]
 [[Category: Dengue virus type 3]]
 [[Category: Flavivirin]]
@@ Line 25: / Line 34: @@
 [[Category: ns3 protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:23:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:54:57 2008''