4ilr: Difference between revisions

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-{{STRUCTURE_4ilr|  PDB=4ilr  |  SCENE=  }}
+==Recognition and Cleavage of a non-structured CRISPR RNA by its Processing Endoribonuclease Cas6==
-===Recognition and Cleavage of a non-structured CRISPR RNA by its Processing Endoribonuclease Cas6===
+<StructureSection load='4ilr' size='340' side='right' caption='[[4ilr]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
-{{ABSTRACT_PUBMED_23454186}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ilr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus_p2 Sulfolobus solfataricus p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ILR FirstGlance]. <br>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pkm|3pkm]], [[4ill|4ill]], [[4ilm|4ilm]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cas6b, SSO2004 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273057 Sulfolobus solfataricus P2])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ilr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ilr RCSB], [http://www.ebi.ac.uk/pdbsum/4ilr PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Clustered regularly interspaced short palindromic repeats (CRISPRs) confer adaptive immunity to prokaryotes through a small RNA-mediated mechanism. Specific endoribonucleases are required by all CRISPR-bearing organisms to process CRISPR RNAs into small RNA that serve as guides for defensive effector complexes. The molecular mechanism of how the endoribonucleases process the class of CRISPR RNA containing no predicted secondary structural features remains largely elusive. Here, we report cocrystal structures of a processing endoribonuclease bound with a noncleavable RNA substrate and its product-like fragment derived from a nonpalindramic repeat. The enzyme stabilizes a short RNA stem-loop structure near the cleavage site and cleaves the phosphodiester bond using an active site comprised of arginine and lysine residues. The distinct RNA binding and cleavage mechanisms underline the diversity in CRISPR RNA processing.
-==About this Structure==
+Recognition and Cleavage of a Nonstructured CRISPR RNA by Its Processing Endoribonuclease Cas6.,Shao Y, Li H Structure. 2013 Feb 27. pii: S0969-2126(13)00017-8. doi:, 10.1016/j.str.2013.01.010. PMID:23454186<ref>PMID:23454186</ref>
-[[4ilr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus_p2 Sulfolobus solfataricus p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILR OCA].
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Sulfolobus solfataricus p2]]
-[[Category: Li, H.]]
+[[Category: Li, H]]
-[[Category: Shao, Y.]]
+[[Category: Shao, Y]]
 [[Category: Hydrolase]]
 [[Category: Rna]]
 [[Category: Rna cleavage]]
 [[Category: Rrm]]