2fbo: Difference between revisions
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[[Image:2fbo.gif|left|200px]] | [[Image:2fbo.gif|left|200px]] | ||
'''Crystal Structure of the Two Tandem V-type Regions of VCBP3 (v-region-containing chitin binding protein) to 1.85 A''' | {{Structure | ||
|PDB= 2fbo |SIZE=350|CAPTION= <scene name='initialview01'>2fbo</scene>, resolution 1.850Å | |||
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|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
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'''Crystal Structure of the Two Tandem V-type Regions of VCBP3 (v-region-containing chitin binding protein) to 1.85 A''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2FBO is a [ | 2FBO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Branchiostoma_floridae Branchiostoma floridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FBO OCA]. | ||
==Reference== | ==Reference== | ||
Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus., Hernandez Prada JA, Haire RN, Allaire M, Jakoncic J, Stojanoff V, Cannon JP, Litman GW, Ostrov DA, Nat Immunol. 2006 Aug;7(8):875-82. Epub 2006 Jun 25. PMID:[http:// | Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus., Hernandez Prada JA, Haire RN, Allaire M, Jakoncic J, Stojanoff V, Cannon JP, Litman GW, Ostrov DA, Nat Immunol. 2006 Aug;7(8):875-82. Epub 2006 Jun 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16799561 16799561] | ||
[[Category: Branchiostoma floridae]] | [[Category: Branchiostoma floridae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: immunoglobulin; vcbp; chitin binding protein; v-type; v set]] | [[Category: immunoglobulin; vcbp; chitin binding protein; v-type; v set]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:50:25 2008'' | ||
Revision as of 17:50, 20 March 2008
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Crystal Structure of the Two Tandem V-type Regions of VCBP3 (v-region-containing chitin binding protein) to 1.85 A
OverviewOverview
Although the origins of genes encoding the rearranging binding receptors remain obscure, it is predicted that their ancestral forms were nonrearranging immunoglobulin-type domains. Variable region-containing chitin-binding proteins (VCBPs) are diversified immune-type molecules found in amphioxus (Branchiostoma floridae), an invertebrate that diverged early in deuterostome phylogeny. To study the potential evolutionary relationships between VCBPs and vertebrate adaptive immune receptors, we solved the structures of both a single V-type domain (to 1.15 A) and a pair of V-type domains (to 1.85 A) from VCBP3. The deduced structures show integral features of the ancestral variable-region fold as well as unique features of variable-region pairing in molecules that may reflect characteristics of ancestral forms of diversified immune receptors found in modern-day vertebrates.
About this StructureAbout this Structure
2FBO is a Single protein structure of sequence from Branchiostoma floridae. Full crystallographic information is available from OCA.
ReferenceReference
Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus., Hernandez Prada JA, Haire RN, Allaire M, Jakoncic J, Stojanoff V, Cannon JP, Litman GW, Ostrov DA, Nat Immunol. 2006 Aug;7(8):875-82. Epub 2006 Jun 25. PMID:16799561
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