2f1g: Difference between revisions

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[[Image:2f1g.gif|left|200px]]<br /><applet load="2f1g" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2f1g.gif|left|200px]]
caption="2f1g, resolution 1.90&Aring;" />
 
'''Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide'''<br />
{{Structure
|PDB= 2f1g |SIZE=350|CAPTION= <scene name='initialview01'>2f1g</scene>, resolution 1.90&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=GNF:N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE'>GNF</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27]
|GENE= CTSS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2F1G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GNF:'>GNF</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1G OCA].  
2F1G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1G OCA].  


==Reference==
==Reference==
Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: heterocyclic P3., Tully DC, Liu H, Alper PB, Chatterjee AK, Epple R, Roberts MJ, Williams JA, Nguyen KT, Woodmansee DH, Tumanut C, Li J, Spraggon G, Chang J, Tuntland T, Harris JL, Karanewsky DS, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1975-80. Epub 2006 Jan 30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16446091 16446091]
Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: heterocyclic P3., Tully DC, Liu H, Alper PB, Chatterjee AK, Epple R, Roberts MJ, Williams JA, Nguyen KT, Woodmansee DH, Tumanut C, Li J, Spraggon G, Chang J, Tuntland T, Harris JL, Karanewsky DS, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1975-80. Epub 2006 Jan 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16446091 16446091]
[[Category: Cathepsin S]]
[[Category: Cathepsin S]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: GNF]]
[[Category: GNF]]
[[Category: GOL]]
[[Category: GOL]]
[[Category: 2-(benzooxazol-2-ylamino) acetamides]]
[[Category: 2-(benzooxazol-2-ylamino) acetamide]]
[[Category: cathepsin s]]
[[Category: cathepsin s]]
[[Category: inhibition]]
[[Category: inhibition]]
[[Category: noncovalent]]
[[Category: noncovalent]]


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