G1SecL05: Difference between revisions
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Lyme disease, discovered in 1975, is a vector- borne disease caused by the inoculation of spirochete borrelia into the skin by members of hard bodied ticks of the family Ixodidae. Symptoms include arthritis at major joints, neurological problems such as reduced memory and poor ability to concentrate, and characteristic lesions erythema migans, more commonly known as the bull’s eye rash. A major outer surface membrane protein of Borrelia, ospA, plays a key role in immunity against Lyme disease through its binding to the antibody LA-2 fab. | Lyme disease, discovered in 1975, is a vector- borne disease caused by the inoculation of spirochete borrelia into the skin by members of hard bodied ticks of the family Ixodidae. Symptoms include arthritis at major joints, neurological problems such as reduced memory and poor ability to concentrate, and characteristic lesions erythema migans, more commonly known as the bull’s eye rash. A major outer surface membrane protein of Borrelia, ospA, plays a key role in immunity against Lyme disease through its binding to the antibody LA-2 fab. | ||
Introduction to the LA-2 | Introduction to the LA-2 OspA | ||
<Structure load='1fj1' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='1fj1' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
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<scene name='G1SecL05/1fj1/1'> Space-filling model with OspA+LA-2 Fab in Pink</scene> | <scene name='G1SecL05/1fj1/1'> Space-filling model with OspA+LA-2 Fab in Pink</scene> | ||
<scene name='G1SecL05/1fj1-condensed/1'>Three variable regions highlights, Tryptophan 216 - Blue, Alanine 208 - Purple, Highly Variable LA-2 Fab + OspA conjunction - Red</scene> | <scene name='G1SecL05/1fj1_chains_labeled/1'>Chains A-E labeled</scene> | ||
<scene name='G1SecL05/1fj1-condensed/1'>Composite Three variable regions highlights, Tryptophan 216 - Blue, Alanine 208 - Purple, Highly Variable LA-2 Fab + OspA conjunction - Red</scene> | |||