Epidermal Growth Factor Receptor: Difference between revisions
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== '''EGFR and Lung Cancers of "Never Smokers"''' == | == '''EGFR and Lung Cancers of "Never Smokers"''' == | ||
<Structure load='2ity' size='500' frame='true' align='right' caption='Structure of EGFR ([[2ity]])' scene='Insert optional scene name here' /> | <Structure load='2ity' size='500' frame='true' align='right' caption='Structure of EGFR complex with the drug gefitinib ([[2ity]])' scene='Insert optional scene name here' /> | ||
Tyrosine kinases in general control critical cellular activities through regulation of signal pathways (3). This regulation is essential for controlling the cell and making sure it acts normally and goes through the normal cell cycle. However, when these kinases are mutated, they can lead to cancer as a result (3). Mutations in EGFR as a result can also lead to cancers, and this is why understanding how EGFR works is an essential aspect for the treatment of certain cancers. In cancer, cells divide rapidly without control and an uncontrolled or unregulated EGF receptor will and can result in uncontrolled cell division. Therefore, inhibition of EGFR can be an essential part of controlling cancers caused by mutations in EGFR. | Tyrosine kinases in general control critical cellular activities through regulation of signal pathways (3). This regulation is essential for controlling the cell and making sure it acts normally and goes through the normal cell cycle. However, when these kinases are mutated, they can lead to cancer as a result (3). Mutations in EGFR as a result can also lead to cancers, and this is why understanding how EGFR works is an essential aspect for the treatment of certain cancers. In cancer, cells divide rapidly without control and an uncontrolled or unregulated EGF receptor will and can result in uncontrolled cell division. Therefore, inhibition of EGFR can be an essential part of controlling cancers caused by mutations in EGFR. | ||