4bh6: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4bh6|  PDB=4bh6  |  SCENE=  }}
+===Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex===
+{{ABSTRACT_PUBMED_23707760}}
-The entry 4bh6 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/CDH1_YEAST CDH1_YEAST]] Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.<ref>PMID:10329618</ref> <ref>PMID:11566880</ref> <ref>PMID:11448992</ref>  [[http://www.uniprot.org/uniprot/ACM1_YEAST ACM1_YEAST]] Negative regulator of GDH1, the activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C), and which is required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1.<ref>PMID:17030612</ref>
-Authors: He, J., Chao, W.C.H., Zhang, Z., Yang, J., Cronin, N., Barford, D.
+==About this Structure==
+[[4bh6]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH6 OCA].
-Description: Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex
+==Reference==
+<ref group="xtra">PMID:023707760</ref><references group="xtra"/><references/>
+[[Category: Saccharomyces cerevisiae]]
+[[Category: Barford, D.]]
+[[Category: Chao, W C.H.]]
+[[Category: Cronin, N.]]
+[[Category: He, J.]]
+[[Category: Yang, J.]]
+[[Category: Zhang, Z.]]
+[[Category: Acm1]]
+[[Category: Anaphase promoting complex]]
+[[Category: Cell cycle]]
+[[Category: D box]]
+[[Category: Ubiquitination]]