4bgd: Difference between revisions
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{{STRUCTURE_4bgd| PDB=4bgd | SCENE= }} | |||
===Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8=== | |||
{{ABSTRACT_PUBMED_23727230}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PRP8_YEAST PRP8_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.<ref>PMID:2835658</ref> <ref>PMID:9150140</ref> <ref>PMID:12773561</ref> <ref>PMID:18779563</ref> | |||
==About this Structure== | |||
[[4bgd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BGD OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023727230</ref><references group="xtra"/><references/> | |||
[[Category: RNA helicase]] | |||
[[Category: Saccharomyces cerevisiae]] | |||
[[Category: Li, J.]] | |||
[[Category: Nagai, K.]] | |||
[[Category: Nguyen, T H.D.]] | |||
[[Category: Retinitis pigmentosa]] | |||
[[Category: Rna helicase]] | |||
[[Category: Spliceosome]] | |||
[[Category: Transcription]] | |||
[[Category: U5 snrnp]] | |||
Revision as of 19:17, 19 June 2013
Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8
Template:ABSTRACT PUBMED 23727230
FunctionFunction
[PRP8_YEAST] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.[1] [2] [3] [4]
About this StructureAbout this Structure
4bgd is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Nguyen TH, Li J, Galej WP, Oshikane H, Newman AJ, Nagai K. Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site. Structure. 2013 May 29. pii: S0969-2126(13)00129-9. doi:, 10.1016/j.str.2013.04.017. PMID:23727230 doi:10.1016/j.str.2013.04.017
- ↑ Jackson SP, Lossky M, Beggs JD. Cloning of the RNA8 gene of Saccharomyces cerevisiae, detection of the RNA8 protein, and demonstration that it is essential for nuclear pre-mRNA splicing. Mol Cell Biol. 1988 Mar;8(3):1067-75. PMID:2835658
- ↑ Abovich N, Rosbash M. Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell. 1997 May 2;89(3):403-12. PMID:9150140
- ↑ McPheeters DS, Muhlenkamp P. Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast. Mol Cell Biol. 2003 Jun;23(12):4174-86. PMID:12773561
- ↑ Yang K, Zhang L, Xu T, Heroux A, Zhao R. Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13817-22. Epub 2008 Sep 8. PMID:18779563