User:Michael Roberts/BIOL115 CaM: Difference between revisions

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[[Image:1ckk.png|left|200px]]

'''

Sequence and structure of EF hands'''

Calmodulin ~~tutorial test~~

The EF hand motif is present in a many proteins and it commonly bestows the ability to bind Ca2+ ions. It was first identified in parvalbumin, a muscle protein. Here we will have a look at the Ca2+-binding protein calmodulin, which possesses four EF hands. Calmodulin and its isoform, troponinC, are important intracellular Ca2+-binding proteins.

The structure on the right, obtained by X-ray crystallography, represents the Ca2+-binding protein calmodulin. It has a dumbell-shaped structure with two identical lobes connected by a central alpha-helix. Each lobe comprises three a helices joined by loops. A helix-loop-helix motif forms the basis of each EF hand.

Click on the 'green links' below to examine this molecule in more detail.

Let us color the two main forms of regular <scene name='Sandbox_LUBIOL115/Structure_plus_ca/1'>secondary structure</scene> in this protein. Alpha helix appears in red, beta sheet in yellow.

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 [[Image:1ckk.png|left|200px]]
+'''
+Sequence and structure of EF hands'''
-Calmodulin tutorial test
+The EF hand motif is present in a many proteins and it commonly bestows the ability to bind Ca2+ ions. It was first identified in parvalbumin, a muscle protein. Here we will have a look at the Ca2+-binding protein calmodulin, which possesses four EF hands. Calmodulin and its isoform, troponinC, are important intracellular Ca2+-binding proteins.
+The structure on the right, obtained by X-ray crystallography, represents the Ca2+-binding protein calmodulin. It has a dumbell-shaped structure with two identical lobes connected by a central alpha-helix. Each lobe comprises three a helices joined by loops. A helix-loop-helix motif forms the basis of each EF hand.
-<Structure load='1CLL' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
+Click on the 'green links' below to examine this molecule in more detail.
+<Structure load='1CLL' size='500' frame='true' align='right' caption='Human calmodulin' scene='Insert optional scene name here' />
 Let us color the two main forms of regular <scene name='Sandbox_LUBIOL115/Structure_plus_ca/1'>secondary structure</scene> in this protein. Alpha helix appears in red, beta sheet in yellow.