4jql: Difference between revisions
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{{STRUCTURE_4jql| PDB=4jql | SCENE= }} | {{STRUCTURE_4jql| PDB=4jql | SCENE= }} | ||
===Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid=== | ===Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid=== | ||
{{ABSTRACT_PUBMED_23554224}} | |||
==Function== | ==Function== | ||
Revision as of 13:32, 24 April 2013
Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic AcidSynthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid
Template:ABSTRACT PUBMED 23554224
FunctionFunction
[HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.[1] [2]
About this StructureAbout this Structure
4jql is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Martinez-Ruiz A, Villanueva L, Gonzalez de Orduna C, Lopez-Ferrer D, Higueras MA, Tarin C, Rodriguez-Crespo I, Vazquez J, Lamas S. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8525-30. Epub 2005 Jun 3. PMID:15937123 doi:10.1073/pnas.0407294102
- ↑ Forsythe HL, Jarvis JL, Turner JW, Elmore LW, Holt SE. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. J Biol Chem. 2001 May 11;276(19):15571-4. Epub 2001 Mar 23. PMID:11274138 doi:10.1074/jbc.C100055200