4j34: Difference between revisions
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{{STRUCTURE_4j34| PDB=4j34 | SCENE= }} | {{STRUCTURE_4j34| PDB=4j34 | SCENE= }} | ||
===Crystal Structure of kynurenine 3-monooxygenase - truncated at position 394 plus HIS tag cleaved.=== | ===Crystal Structure of kynurenine 3-monooxygenase - truncated at position 394 plus HIS tag cleaved.=== | ||
{{ABSTRACT_PUBMED_23575632}} | |||
==Function== | ==Function== | ||
Revision as of 13:33, 24 April 2013
Crystal Structure of kynurenine 3-monooxygenase - truncated at position 394 plus HIS tag cleaved.Crystal Structure of kynurenine 3-monooxygenase - truncated at position 394 plus HIS tag cleaved.
Template:ABSTRACT PUBMED 23575632
FunctionFunction
[KMO_YEAST] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.[1] [2]
About this StructureAbout this Structure
4j34 is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Panozzo C, Nawara M, Suski C, Kucharczyka R, Skoneczny M, Becam AM, Rytka J, Herbert CJ. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Lett. 2002 Apr 24;517(1-3):97-102. PMID:12062417
- ↑ Giorgini F, Guidetti P, Nguyen Q, Bennett SC, Muchowski PJ. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat Genet. 2005 May;37(5):526-31. Epub 2005 Apr 3. PMID:15806102 doi:ng1542