4ixh: Difference between revisions
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{{STRUCTURE_4ixh| PDB=4ixh | SCENE= }} | {{STRUCTURE_4ixh| PDB=4ixh | SCENE= }} | ||
===Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum=== | ===Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum=== | ||
{{ABSTRACT_PUBMED_23668331}} | |||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:023668331</ref><references group="xtra"/><references/> | ||
[[Category: Cryptosporidium parvum]] | [[Category: Cryptosporidium parvum]] | ||
[[Category: IMP dehydrogenase]] | [[Category: IMP dehydrogenase]] | ||
Revision as of 12:21, 19 June 2013
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvumCrystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum
Template:ABSTRACT PUBMED 23668331
FunctionFunction
[IMDH_CRYPV] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[1]
About this StructureAbout this Structure
4ixh is a 4 chain structure with sequence from Cryptosporidium parvum. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5'-Monophosphate Dehydrogenase. J Med Chem. 2013 May 23;56(10):4028-43. doi: 10.1021/jm400241j. Epub 2013 May 13. PMID:23668331 doi:10.1021/jm400241j
- ↑ Umejiego NN, Li C, Riera T, Hedstrom L, Striepen B. Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design. J Biol Chem. 2004 Sep 24;279(39):40320-7. Epub 2004 Jul 21. PMID:15269207 doi:10.1074/jbc.M407121200
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Cryptosporidium parvum
- IMP dehydrogenase
- Andesrson, W F.
- CSGID, Center for Structural Genomics of Infectious Diseases.
- Gu, M.
- Hedstrom, L.
- Joachimiak, A.
- Kavitha, M.
- Kim, Y.
- Makowska-Grzyska, M.
- Alpha-beta fold
- Center for structural genomics of infectious disease
- Csgid
- National institute of allergy and infectious disease
- Niaid
- Oxidoreductase
- Structural genomic
- Tim barrel