2dw1: Difference between revisions

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Revision as of 17:32, 20 March 2008

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, resolution 2.5Å

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Crystal structure of VAP2 from Crotalus atrox venom (Form 2-2 crystal)

OverviewOverview

Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.

About this StructureAbout this Structure

2DW1 is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:17485084

Page seeded by OCA on Thu Mar 20 16:32:17 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:2dw1.jpg|left|200px]]<br /><applet load="2dw1" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2dw1.jpg|left|200px]]
-caption="2dw1, resolution 2.5&Aring;" />
-'''Crystal structure of VAP2 from Crotalus atrox venom (Form 2-2 crystal)'''<br />
+ {{Structure
+|PDB= 2dw1 |SIZE=350|CAPTION= <scene name='initialview01'>2dw1</scene>, resolution 2.5&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=GM6:3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE'>GM6</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''Crystal structure of VAP2 from Crotalus atrox venom (Form 2-2 crystal)'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-DW1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=GM6:'>GM6</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DW1 OCA].
+DW1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DW1 OCA].
 ==Reference==
-Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17485084 17485084]
+Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17485084 17485084]
 [[Category: Crotalus atrox]]
 [[Category: Single protein]]
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 [[Category: svmp]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:03:16 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:32:17 2008''