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{{STRUCTURE_4efb| PDB=4efb | SCENE= }}  
==Crystal structure of DNA ligase==
===Crystal structure of DNA ligase===
<StructureSection load='4efb' size='340' side='right' caption='[[4efb]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4efb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EFB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0OW:4-AMINO-2-(CYCLOPENTYLOXY)-6-{[(1R,2S)-2-HYDROXYCYCLOPENTYL]OXY}PYRIMIDINE-5-CARBOXAMIDE'>0OW</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eeq|4eeq]], [[4efe|4efe]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(NAD(+)) DNA ligase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.2 6.5.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4efb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4efb RCSB], [http://www.ebi.ac.uk/pdbsum/4efb PDBsum]</span></td></tr>
</table>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA]] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).
*[[DNA ligase|DNA ligase]]
 
__TOC__
==About this Structure==
</StructureSection>
[[4efb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFB OCA].
[[Category: Charifson, P]]
[[Category: Charifson, P.]]
[[Category: Wang, T]]
[[Category: Wang, T.]]
[[Category: Wei, Y]]
[[Category: Wei, Y.]]
[[Category: Xu, W]]
[[Category: Xu, W.]]
[[Category: Adenylation]]
[[Category: Adenylation]]
[[Category: Alpha-beta protein]]
[[Category: Alpha-beta protein]]
[[Category: Enzyme]]
[[Category: Enzyme]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Ligase-ligase inhibitor complex]]

Revision as of 14:23, 21 December 2014

Crystal structure of DNA ligaseCrystal structure of DNA ligase

Structural highlights

4efb is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:DNA ligase (NAD(+)), with EC number 6.5.1.2
Resources:FirstGlance, OCA, RCSB, PDBsum

See Also

4efb, resolution 2.20Å

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