4jw3: Difference between revisions
Jump to navigation
Jump to search
m Protected "4jw3" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4jw3| PDB=4jw3 | SCENE= }} | |||
===Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep)=== | |||
{{ABSTRACT_PUBMED_24014183}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/NCZS_STRML NCZS_STRML]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks. | |||
==About this Structure== | |||
[[4jw3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Gekko_coi Gekko coi] and [http://en.wikipedia.org/wiki/Streptomyces_malayensis Streptomyces malayensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JW3 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024014183</ref><references group="xtra"/><references/> | |||
[[Category: Gekko coi]] | |||
[[Category: Streptomyces malayensis]] | |||
[[Category: Chevrel, A.]] | |||
[[Category: Desmadril, M.]] | |||
[[Category: Fourati-Kammoun, Z.]] | |||
[[Category: Graille, M.]] | |||
[[Category: Guellouz, A.]] | |||
[[Category: Minard, P.]] | |||
[[Category: Tilbeurgh, H van.]] | |||
[[Category: Urvoas, A.]] | |||
[[Category: Valerio-Lepiniec, M.]] | |||
[[Category: Alpha-helical protein]] | |||
[[Category: Dna binding protein-de novo protein complex]] | |||
[[Category: Ncs 3tes24 variant]] | |||
[[Category: Protein engineered to interact with protein of interest]] | |||
Revision as of 11:10, 29 September 2013
Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep)Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep)
Template:ABSTRACT PUBMED 24014183
FunctionFunction
[NCZS_STRML] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
About this StructureAbout this Structure
4jw3 is a 4 chain structure with sequence from Gekko coi and Streptomyces malayensis. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Guellouz A, Valerio-Lepiniec M, Urvoas A, Chevrel A, Graille M, Fourati-Kammoun Z, Desmadril M, van Tilbeurgh H, Minard P. Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep). PLoS One. 2013 Aug 27;8(8):e71512. doi: 10.1371/journal.pone.0071512. PMID:24014183 doi:10.1371/journal.pone.0071512