4jtc: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4jtc|  PDB=4jtc  |  SCENE=  }}
+===Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin in Cs+===
+{{ABSTRACT_PUBMED_23705070}}
-The entry 4jtc is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/KCAB2_RAT KCAB2_RAT]] Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. [[http://www.uniprot.org/uniprot/KAX11_LEIQH KAX11_LEIQH]] Potent selective inhibitor of high conductance (maxi-K), different medium and small conductance calcium-activated potassium channels (KCa/KCNM), as well as a voltage-dependent potassium channel (Kv1.3/KCNA3). It appears to block channel activity by a simple bimolecular inhibition process.<ref>PMID:15118082</ref>   Has a pH-specific antimicrobial activity against bacteria (B.subtilis, E.coli and S.aureus) and the fungus C.albicans.<ref>PMID:15118082</ref>  [[http://www.uniprot.org/uniprot/KCNA2_RAT KCNA2_RAT]] Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.<ref>PMID:7544443</ref>
-Authors: Banerjee, A., Lee, A., Campbell, E., MacKinnon, R.
+==About this Structure==
+[[4jtc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JTC OCA].
-Description: Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin in Cs+
+==Reference==
+<ref group="xtra">PMID:023705070</ref><references group="xtra"/><references/>
+[[Category: Leiurus quinquestriatus hebraeus]]
+[[Category: Rattus norvegicus]]
+[[Category: Banerjee, A.]]
+[[Category: Campbell, E.]]
+[[Category: Lee, A.]]
+[[Category: MacKinnon, R.]]
+[[Category: Pore blocking toxin]]
+[[Category: Potassium channel]]
+[[Category: Protein-protein complex]]
+[[Category: Transport protein-toxin complex]]