2dq7: Difference between revisions
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[[Image:2dq7.gif|left|200px]] | [[Image:2dq7.gif|left|200px]] | ||
'''Crystal Structure of Fyn kinase domain complexed with staurosporine''' | {{Structure | ||
|PDB= 2dq7 |SIZE=350|CAPTION= <scene name='initialview01'>2dq7</scene>, resolution 2.8Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] | |||
|GENE= | |||
}} | |||
'''Crystal Structure of Fyn kinase domain complexed with staurosporine''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2DQ7 is a [ | 2DQ7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DQ7 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of human Fyn kinase domain complexed with staurosporine., Kinoshita T, Matsubara M, Ishiguro H, Okita K, Tada T, Biochem Biophys Res Commun. 2006 Aug 4;346(3):840-4. Epub 2006 Jun 13. PMID:[http:// | Structure of human Fyn kinase domain complexed with staurosporine., Kinoshita T, Matsubara M, Ishiguro H, Okita K, Tada T, Biochem Biophys Res Commun. 2006 Aug 4;346(3):840-4. Epub 2006 Jun 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16782058 16782058] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
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[[Category: staurosporine]] | [[Category: staurosporine]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:30:07 2008'' | ||
Revision as of 17:30, 20 March 2008
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| , resolution 2.8Å | |||||||
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| Ligands: | |||||||
| Activity: | Non-specific protein-tyrosine kinase, with EC number 2.7.10.2 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Fyn kinase domain complexed with staurosporine
OverviewOverview
The tyrosine kinase Fyn is a member of the Src kinase family. Besides the role of Fyn in T cell signal transduction in concert with Lck, its excess activity in the brain is involved with conditions such as Alzheimer's and Parkinson's diseases. Therefore, inhibition of Fyn kinase may help counteract these nervous system disorders. Here, we solved the crystal structure of the human Fyn kinase domain complexed with staurosporine, a potent kinase inhibitor, at 2.8 A resolution. Staurosporine binds to the ATP-binding site of Fyn in a similar manner as in the Lck- and Csk-complexes. The small structural differences in the staurosporine-binding and/or -unbinding region among the three kinase domains may help obtaining the selective inhibitors against the respective kinases.
About this StructureAbout this Structure
2DQ7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure of human Fyn kinase domain complexed with staurosporine., Kinoshita T, Matsubara M, Ishiguro H, Okita K, Tada T, Biochem Biophys Res Commun. 2006 Aug 4;346(3):840-4. Epub 2006 Jun 13. PMID:16782058
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