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| {{STRUCTURE_3jv5| PDB=3jv5 | SCENE= }}
| | ==Crystal structure of the dimerization domains p52 homodimer== |
| ===Crystal structure of the dimerization domains p52 homodimer===
| | <StructureSection load='3jv5' size='340' side='right' caption='[[3jv5]], [[Resolution|resolution]] 2.65Å' scene=''> |
| | | == Structural highlights == |
| ==Function== | | <table><tr><td colspan='2'>[[3jv5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JV5 FirstGlance]. <br> |
| [[http://www.uniprot.org/uniprot/NFKB2_MOUSE NFKB2_MOUSE]] NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65 (By similarity). | | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jtc|3jtc]], [[3juz|3juz]], [[3jv0|3jv0]], [[3jv4|3jv4]], [[3jv6|3jv6]]</td></tr> |
| | | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">p52 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| ==About this Structure== | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jv5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jv5 RCSB], [http://www.ebi.ac.uk/pdbsum/3jv5 PDBsum]</span></td></tr> |
| [[3jv5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JV5 OCA]. | | </table> |
| | __TOC__ |
| | </StructureSection> |
| [[Category: Mus musculus]] | | [[Category: Mus musculus]] |
| [[Category: Ghosh, G.]] | | [[Category: Ghosh, G]] |
| [[Category: Huang, D B.]] | | [[Category: Huang, D B]] |
| [[Category: Vu, D.]] | | [[Category: Vu, D]] |
| [[Category: Activator]] | | [[Category: Activator]] |
| [[Category: Ank repeat]] | | [[Category: Ank repeat]] |