4jnm: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jnm|  PDB=4jnm  |  SCENE=  }}
+===Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties===
+{{ABSTRACT_PUBMED_23668988}}
-The entry 4jnm is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
-Authors: Gunzner-Toste, J., Zhao, G., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Fu, B., Han, B., Ho, Y., Kley, N., Liederer, B., Lin, J., Mukadam, S., O'Brien, T., Reynolds, D.J., Sharma, G., Skelton, N., Smith, C.C., Oh, A., Wang, W., Wang, Z., Xiao, Y., Yuen, P., Zak, M., Zhang, L., Zheng, X., Bair, K.W., Dragovich, P.S.
+==About this Structure==
+[[4jnm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNM OCA].
-Description: Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties
+==Reference==
+<ref group="xtra">PMID:023668988</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Nicotinamide phosphoribosyltransferase]]
+[[Category: Bair, K W.]]
+[[Category: Bauer, P.]]
+[[Category: Baumeister, T.]]
+[[Category: Brien, T O.]]
+[[Category: Buckmelter, A J.]]
+[[Category: Caligiuri, M.]]
+[[Category: Clodfelter, K H.]]
+[[Category: Dragovich, P S.]]
+[[Category: Fu, B.]]
+[[Category: Gunzner-Toste, J.]]
+[[Category: Han, B.]]
+[[Category: Ho, Y.]]
+[[Category: Kley, N.]]
+[[Category: Liederer, B.]]
+[[Category: Lin, J.]]
+[[Category: Mukadam, S.]]
+[[Category: Oh, A.]]
+[[Category: Reynolds, D J.]]
+[[Category: Sharma, G.]]
+[[Category: Skelton, N.]]
+[[Category: Smith, C C.]]
+[[Category: Wang, W.]]
+[[Category: Wang, Z.]]
+[[Category: Xiao, Y.]]
+[[Category: Yuen, P.]]
+[[Category: Zak, M.]]
+[[Category: Zhang, L.]]
+[[Category: Zhao, G.]]
+[[Category: Zheng, X.]]
+[[Category: Transferase-transferase inhibitor complex]]