1gf2: Difference between revisions

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-{{Theoretical_model}}
+==TERTIARY STRUCTURES, RECEPTOR BINDING, AND ANTIGENICITY OF INSULINLIKE GROWTH FACTORS==
+<StructureSection load='1gf2' size='340' side='right' caption='[[1gf2]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GF2 FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gf2 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1gf2 PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Three-dimensional models for human insulinlike growth factors (IGF-I and IGF-II) have been constructed by using interactive molecular graphics. It is suggested that the two growth factors have structures in which the A and B chains and the hydrophobic cores are identical to those of insulin. The conformations of the connecting peptides and COOH-terminal extensions are predicted by statistical methods but the structures are limited by the constraints implied by the insulinlike part. The models explain the nonsuppressibility by anti-insulin antibodies of the IGFs and show that part of the insulin receptor-binding region is conserved, which explains the growth factors' ability to bind insulin receptors.
-{{STRUCTURE_1gf2|  PDB=1gf2  |  SCENE=  }}
+Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors.,Blundell TL, Bedarkar S, Humbel RE Fed Proc. 1983 Jun;42(9):2592-7. PMID:6189745<ref>PMID:6189745</ref>
-===TERTIARY STRUCTURES, RECEPTOR BINDING, AND ANTIGENICITY OF INSULINLIKE GROWTH FACTORS===
-{{ABSTRACT_PUBMED_6189745}}
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:006189745</ref><references group="xtra"/><references/>
+</div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Bedarkar, S]]
 [[Category: Blundell, T L]]
 [[Category: Humbel, R E]]