4j6g: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4j6g| PDB=4j6g | SCENE= }} | {{STRUCTURE_4j6g| PDB=4j6g | SCENE= }} | ||
===CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX=== | ===CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. [[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4j6g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6G OCA]. | [[4j6g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6G OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Almo, S C.]] | [[Category: Almo, S C.]] | ||
Revision as of 03:25, 4 April 2013
CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEXCRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX
FunctionFunction
[TNF14_HUMAN] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. [TNF6B_HUMAN] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.[1]
About this StructureAbout this Structure
4j6g is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Zhan C, Patskovsky Y, Yan Q, Li Z, Ramagopal U, Cheng H, Brenowitz M, Hui X, Nathenson SG, Almo SC. Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure. 2011 Feb 9;19(2):162-71. PMID:21300286 doi:10.1016/j.str.2010.12.004
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Homo sapiens
- Almo, S C.
- Bhosle, R C.
- Bonanno, J B.
- IFN, Atoms-to-Animals:.The Immune Function Network.
- Liu, W.
- NYSGRC, New York Structural Genomics Research Consortium.
- Nathenson, S G.
- Zhan, C.
- Atoms-to-animals: the immune function network
- Bind tnf receptor hvem and ltbr
- Cytokine
- Dcr3
- Ifn
- Immune system
- Jelly-roll fold
- Light
- Ltbr
- Membrane
- N-glycosylation
- New hvem
- New york structural genomics research consortium
- Nysgrc
- Protein structure initiative
- Psi-biology
- Secreted protein
- Structural genomic
- Tnf
- Tnf14
- Tnfr