2bct: Difference between revisions

Revision as of 17:00, 20 March 2008

, resolution 2.9Å

Coordinates:

THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN

OverviewOverview

Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. The 12 repeats form a superhelix of helices that features a long, positively charged groove. Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove.

About this StructureAbout this Structure

2BCT is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:9298899

Page seeded by OCA on Thu Mar 20 16:00:14 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2bct.gif|left|200px]]<br /><applet load="2bct" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2bct.gif|left|200px]]
-caption="2bct, resolution 2.9&Aring;" />
-'''THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN'''<br />
+ {{Structure
+|PDB= 2bct |SIZE=350|CAPTION= <scene name='initialview01'>2bct</scene>, resolution 2.9&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE=
+}}
+'''THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-BCT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCT OCA].
+BCT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCT OCA].
 ==Reference==
-Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9298899 9298899]
+Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9298899 9298899]
 [[Category: Mus musculus]]
 [[Category: Single protein]]
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 [[Category: structural protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:36:32 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:00:14 2008''