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OCA

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 ===Solution structure of the Wilson ATPase N-domain in the presence of ATP===
 {{ABSTRACT_PUBMED_16567646}}
+==Disease==
+[[http://www.uniprot.org/uniprot/ATP7B_HUMAN ATP7B_HUMAN]] Defects in ATP7B are the cause of Wilson disease (WD) [MIM:[http://omim.org/entry/277900 277900]]. WD is an autosomal recessive disorder of copper metabolism in which copper cannot be incorporated into ceruloplasmin in liver, and cannot be excreted from the liver into the bile. Copper accumulates in the liver and subsequently in the brain and kidney. The disease is characterized by neurologic manifestations and signs of cirrhosis.<ref>PMID:8298641</ref><ref>PMID:7626145</ref><ref>PMID:8533760</ref><ref>PMID:8938442</ref><ref>PMID:8931691</ref><ref>PMID:8782057</ref><ref>PMID:9311736</ref><ref>PMID:9772425</ref><ref>PMID:9222767</ref><ref>PMID:8980283</ref><ref>PMID:9887381</ref><ref>PMID:9482578</ref><ref>PMID:9554743</ref><ref>PMID:9452121</ref><ref>PMID:9671269</ref><ref>PMID:9829905</ref><ref>PMID:10194254</ref><ref>PMID:10447265</ref><ref>PMID:10502776</ref><ref>PMID:10502777</ref><ref>PMID:10051024</ref><ref>PMID:10544227</ref><ref>PMID:10453196</ref><ref>PMID:11216666</ref><ref>PMID:11093740</ref><ref>PMID:10790207</ref><ref>PMID:10721669</ref><ref>PMID:11043508</ref><ref>PMID:11180609</ref><ref>PMID:11690702</ref><ref>PMID:11243728</ref><ref>PMID:11954751</ref><ref>PMID:12544487</ref><ref>PMID:12325021</ref><ref>PMID:12376745</ref><ref>PMID:14986826</ref><ref>PMID:14639035</ref><ref>PMID:15024742</ref><ref>PMID:15557537</ref><ref>PMID:14966923</ref><ref>PMID:15845031</ref><ref>PMID:15811015</ref><ref>PMID:15952988</ref><ref>PMID:16207219</ref><ref>PMID:16283883</ref><ref>PMID:16088907</ref><ref>PMID:15967699</ref><ref>PMID:17718866</ref><ref>PMID:18373411</ref><ref>PMID:18203200</ref><ref>PMID:21682854</ref>
+==Function==
+[[http://www.uniprot.org/uniprot/ATP7B_HUMAN ATP7B_HUMAN]] Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:016567646</ref><references group="xtra"/>
+<ref group="xtra">PMID:016567646</ref><references group="xtra"/><references/>
 [[Category: Copper-exporting ATPase]]
 [[Category: Homo sapiens]]