Estrogen receptor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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+<StructureSection load='Estr1.pdb' size='500' side='right' scene='Journal:JMEDCHEM:1/Cv/2' caption=''>
 [[Image:1gwr.png|left|200px|thumb|Crystal Structure of Human estrogen receptor [[1gwr]]]]
-{{STRUCTURE_1a52|  PDB=1a52  | SIZE=400| SCENE= |right|CAPTION=Human estrogen receptor α ligand-binding domain dimer complex with estradiol and Au+1 ion [[1a52]] }}
+{{Clear}}
-<!--
+'''Estrogen receptors''' (ER) are activated by the hormone estrogen (EST).  The activated ER binds DNA and regulates the activity of many genes.  There are 2 forms of ER: α and β and ER dimers can be of αα, ββ and αβ.  ER is composed of 5 domains: N terminal A/B domain can transactivate transcription without binding estrogen; C domain (DBD) binds to Estrogen response elements of DNA; D domain is a hinge region; E domain is ligand binding (LBD) as well as binding the coactivator and corepressor proteins and transactivates gene transcription.
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-'''Estrogen receptors''' (ER) are activated by the hormone estrogen (EST).  The activated ER binds DNA and regulates the activity of many genes.  There are 2 forms of ER: α and β and ER dimers can be of αα, ββ and αβ.  ER is composed of 5 domains: N terminal A/B domain can transactivate transcription without binding estrogen; C domain (DBD) binds to Estrogen response elements of DNA; D domain is a hinge region; E domain is ligand binding (LBD) as well as binding the coactivator and corepressor proteins and transactivates gene transcription.
-<StructureSection load='Estr1.pdb' size='500' side='right' scene='Journal:JMEDCHEM:1/Cv/2' caption=''>
 '''Structure of estradiol metal chelate and  estrogen receptor complex: The basis for designing a new class of SERMs <ref>PMID: 21473635</ref>'''