Anthrax edema factor: Difference between revisions
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{{STRUCTURE_1pk0| PDB=1pk0 | SIZE=400| SCENE= |right|CAPTION=EF trimer (grey, green, pink) complex with calmodulin (yellow, magenta, cyan) and adenine diphosphate derivative, Ca+2 and Yt+3 ions [[1pk0]] }} | {{STRUCTURE_1pk0| PDB=1pk0 | SIZE=400| SCENE= |right|CAPTION=EF trimer (grey, green, pink) complex with calmodulin (yellow, magenta, cyan) and adenine diphosphate derivative, Ca+2 (light green) and Yt+3 (green) ions [[1pk0]] }} | ||
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Revision as of 12:09, 3 December 2013
Template:STRUCTURE 1pk0 Anthrax edema factor (EF) is an enzyme which is part of the Bacillus anthracis anthrax toxin. The anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. It causes the cellular level of cAMP to increase thus upsetting water homeostasis and causing disruption of signaling pathways.
3D structures of anthrax edema factor3D structures of anthrax edema factor
Updated on 03-December-2013
1lvc – EF adenylate cyclase domain + calmodulin + anthraniloyl-deoxy-ATP
1pk0 - EF adenylate cyclase domain + calmodulin + phosphonylmethoxyethyl-ADP
1s26 - EF adenylate cyclase domain + calmodulin + methylene-ATP
1sk6 - EF adenylate cyclase domain + calmodulin + pyrophosphate + cAMP
1xfu - EF residues 64-800 (mutant) + calmodulin
1xfv - EF residues 33-800 + calmodulin + deoxy-ATP
1xfw - EF residues 33-800 + calmodulin + cAMP
1xfx, 1xfy, 1xfz - EF residues 33-800 + calmodulin