4f0z: Difference between revisions
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{{STRUCTURE_4f0z| PDB=4f0z | SCENE= }} | {{STRUCTURE_4f0z| PDB=4f0z | SCENE= }} | ||
===Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L=== | ===Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L=== | ||
{{ABSTRACT_PUBMED_23468591}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref><ref>PMID:18838687</ref> [[http://www.uniprot.org/uniprot/VF238_ASFM2 VF238_ASFM2]] Inhibits activation of the NF-kappa-B transcription factor by preventing binding of NF-kappa-B subunits RELA and NFKB3 to DNA. Inhibits also the activity of the calcium/calmodulin-regulated phosphatase calcineurin (By similarity). [[http://www.uniprot.org/uniprot/CANB1_HUMAN CANB1_HUMAN]] Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. | |||
==About this Structure== | ==About this Structure== | ||
[[4f0z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/African_swine_fever_virus_malawi_lil_20/1 African swine fever virus malawi lil 20/1] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F0Z OCA]. | [[4f0z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/African_swine_fever_virus_malawi_lil_20/1 African swine fever virus malawi lil 20/1] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F0Z OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: African swine fever virus malawi lil 20/1]] | [[Category: African swine fever virus malawi lil 20/1]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||