4j82: Difference between revisions
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{{STRUCTURE_4j82| PDB=4j82 | SCENE= }} | |||
===Crystal structure of beta'-COP/Insig-2 complex=== | |||
{{ABSTRACT_PUBMED_23481256}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/COPB2_YEAST COPB2_YEAST]] The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.<ref>PMID:17101773</ref> [[http://www.uniprot.org/uniprot/INSI2_HUMAN INSI2_HUMAN]] Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.<ref>PMID:12242332</ref><ref>PMID:16606821</ref> | |||
==About this Structure== | |||
[[4j82]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J82 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Saccharomyces cerevisiae]] | |||
[[Category: Goldberg, J.]] | |||
[[Category: Ma, W.]] | |||
[[Category: Beta propeller domain]] | |||
[[Category: Dilysine motif]] | |||
[[Category: Er retrieval]] | |||
[[Category: Protein transport]] | |||
[[Category: Vesicle trafficking]] |