4j2x: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4j2x| PDB=4j2x | SCENE= }} | |||
===CSL (RBP-Jk) with corepressor KyoT2 bound to DNA=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SUH_MOUSE SUH_MOUSE]] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.<ref>PMID:7566092</ref> [[http://www.uniprot.org/uniprot/FHL1_MOUSE FHL1_MOUSE]] May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems. | |||
==About this Structure== | |||
[[4j2x]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J2X OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | |||
[[Category: Collins, K J.]] | |||
[[Category: Kovall, R A.]] | |||
[[Category: Dna binding]] | |||
[[Category: Lim domain containing protein]] | |||
[[Category: Nucleus]] | |||
[[Category: Transcription factor corepressor]] | |||
[[Category: Transcription-dna binding protein-dna complex]] | |||
Revision as of 10:42, 6 November 2013
CSL (RBP-Jk) with corepressor KyoT2 bound to DNACSL (RBP-Jk) with corepressor KyoT2 bound to DNA
FunctionFunction
[SUH_MOUSE] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.[1] [FHL1_MOUSE] May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems.
About this StructureAbout this Structure
4j2x is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A. Signalling downstream of activated mammalian Notch. Nature. 1995 Sep 28;377(6547):355-8. PMID:7566092 doi:http://dx.doi.org/10.1038/377355a0