3guq: Difference between revisions

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-[[Image:3guq.png|left|200px]]
+==Crystal structure of novel carcinogenic factor of H. pylori==
+<StructureSection load='3guq' size='340' side='right' caption='[[3guq]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3guq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GUQ FirstGlance]. <br>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HP0596, HP_0596 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3guq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3guq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3guq RCSB], [http://www.ebi.ac.uk/pdbsum/3guq PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Stomach cancer is strongly associated with infection by Helicobacter pylori. In 2005, we identified a new H. pylori gene encoding a TNF-alpha inducing protein (Tipalpha) that acts as a carcinogenic factor. Tipalpha is secreted from H. pylori as a homodimer whose subunits are linked by disulfide bonds. We also characterized a Tipalpha deletion mutant (del-Tipalpha) that lacks the N-terminal six amino acid residues (LQACTC), including two cysteines (C5 and C7) that form disulfide bonds, but nonetheless shows a weak ability to induce TNF-alpha expression. Here we report that del-Tipalpha has a novel elongated structure containing a 40-A-long alpha helix, and forms a heart-shaped homodimer via non-covalent bonds. Moreover, their circular dichroism spectra strongly suggest that the structures of the del-Tipalpha and Tipalpha homodimers are very similar. del-Tipalpha's unique mode of dimer formation provides important insight into protein-protein interactions and into the mechanism underlying the carcinogenicity of H. pylori infection.
-{{STRUCTURE_3guq|  PDB=3guq  |  SCENE=  }}
+Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein.,Tsuge H, Tsurumura T, Utsunomiya H, Kise D, Kuzuhara T, Watanabe T, Fujiki H, Suganuma M Biochem Biophys Res Commun. 2009 Oct 16;388(2):193-8. Epub 2009 Jul 28. PMID:19643085<ref>PMID:19643085</ref>
-===Crystal structure of novel carcinogenic factor of H. pylori===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_19643085}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[3guq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GUQ OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:019643085</ref><references group="xtra"/>
 [[Category: Helicobacter pylori]]
-[[Category: Fujiki, H.]]
+[[Category: Fujiki, H]]
-[[Category: Kise, D.]]
+[[Category: Kise, D]]
-[[Category: Kuzuhara, T.]]
+[[Category: Kuzuhara, T]]
-[[Category: Suganuma, M.]]
+[[Category: Suganuma, M]]
-[[Category: Tsuge, H.]]
+[[Category: Tsuge, H]]
-[[Category: Tsurumura, T.]]
+[[Category: Tsurumura, T]]
-[[Category: Utsunomiya, H.]]
+[[Category: Utsunomiya, H]]
 [[Category: Long alpha helix]]
 [[Category: Novel carcinogenic factor]]
 [[Category: Tnfa inducing factor]]
 [[Category: Toxin]]