4dvv: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4dvv| PDB=4dvv | SCENE= }} | {{STRUCTURE_4dvv| PDB=4dvv | SCENE= }} | ||
===Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-I-261=== | ===Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-I-261=== | ||
{{ABSTRACT_PUBMED_24489681}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q0ED31_9HIV1 Q0ED31_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[4dvv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4dvv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVV OCA]. | ||
[[Category: | |||
==Reference== | |||
<ref group="xtra">PMID:024489681</ref><references group="xtra"/><references/> | |||
[[Category: 9hiv1]] | |||
[[Category: Kwon, Y D.]] | [[Category: Kwon, Y D.]] | ||
[[Category: Kwong, P D.]] | [[Category: Kwong, P D.]] | ||
Revision as of 12:17, 19 March 2014
Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-I-261Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-I-261
Template:ABSTRACT PUBMED 24489681
FunctionFunction
[Q0ED31_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
About this StructureAbout this Structure
4dvv is a 2 chain structure with sequence from 9hiv1. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Kwon YD, Lalonde JM, Yang Y, Elban MA, Sugawara A, Courter JR, Jones DM, Smith AB 3rd, Debnath AK, Kwong PD. Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. PLoS One. 2014 Jan 28;9(1):e85940. doi: 10.1371/journal.pone.0085940. eCollection, 2014. PMID:24489681 doi:http://dx.doi.org/10.1371/journal.pone.0085940