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{{STRUCTURE_4dtt| PDB=4dtt | SCENE= }} | {{STRUCTURE_4dtt| PDB=4dtt | SCENE= }} | ||
===Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367=== | ===Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4dtt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4dtt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DTT OCA]. | ||
[[Category: | |||
==See Also== | |||
*[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]] | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Human]] | |||
[[Category: Insulysin]] | [[Category: Insulysin]] | ||
[[Category: Deprez, B.]] | [[Category: Deprez, B.]] | ||
Revision as of 10:25, 16 April 2014
Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367
FunctionFunction
[IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.[1] [2] [3]
About this StructureAbout this Structure
4dtt is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000 Mar 1;20(5):1657-65. PMID:10684867
- ↑ Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5. PMID:17613531 doi:10.1074/jbc.M701590200
- ↑ Malito E, Ralat LA, Manolopoulou M, Tsay JL, Wadlington NL, Tang WJ. Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme. Biochemistry. 2008 Nov 6. PMID:18986166 doi:10.1021/bi801192h